United States securities and exchange commission logo August 25, 2020 David J. Mazzo, PhD President and Chief Executive Officer Caladrius Biosciences, Inc. 110 Allen Road, 2nd Floor Basking Ridge, NJ 07920 Re: Caladrius Biosciences, Inc. Registration Statement on Form S-3 Filed August 18, 2020 File No. 333-248100 Dear Dr. Mazzo: This is to advise you that we have not reviewed and will not review your registration statement. Please refer to Rules 460 and 461 regarding requests for acceleration. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Please contact Deanna Virginio at 202-551-4530 with any questions. Sincerely, Division of Corporation Finance Office of Life Sciences cc: Stephanie Leopold, Esq.